Company in brief

Oncopeptides is a clinical development pharmaceutical company focused on bringing anti-cancer research as treatments for the benefit of patients. The company was established in 2000 and is based in Stockholm, Sweden.

Oncopeptides has developed Ygalo, the first targeted cytotoxic therapy intended for use in the treatment of multiple myeloma. The first indication is late-stage relapsed and refractory multiple myeloma.

Ygalo is unique in its ability to kill cancer cells up to fifty-times better than exiting cytotoxic treatments, without a similar increase in effect on the patient’s bone marrow, as demonstrated in clinical and pre-clinical studies.

Comparing clinical data between Ygalo and the current standard of care in late-stage multiple myeloma indicates that treatment with Ygalo increases overall survival, progression free survival and the number of patients with significant tumour burden reduction as well as being better tolerated by patients.

Ygalo has undergone the US Food and Drug Administration’s Special Protocol Assessment process for a pivotal Phase 3 study of patients with late-stage multiple myeloma. The study will commence shortly and will compare Ygalo directly against the current standard of care. The successful conclusion of this study will likely lead to regulatory approval in the US and Europe.

Each year, approximately three in every 10,000 people are diagnosed with multiple myeloma*. While multiple myeloma can affect people of any age, the average age of diagnosis is 70 years of age. As there is no cure for multiple myeloma, a key focus of treatment is extending and improving the quality of life for patients, particularly in the final stages of the disease.

In 2016, global sales of the current standard of care for comparable late-stage multiple myeloma patients represented approximately USD 1.3 billion. This market is expected to grow to a value of USD 2.3 billion* by 2019 driven mainly by an ageing population and improved treatments.

* National Cancer Institute, SEER Cancer Statistics Review 1975-2013 (2016) for patients in USA and GlobalData (2015).
* GlobalData (2016). Sales data for lenalidomide and pomalidomide are based on an average analysts’ estimate and refers to global sales